Ryan Salame

Biotech & Pharma

About 2¾ hours · Last updated October 2026

How a drug is discovered, tested, approved, made, priced, and copied, with the odds and costs at each phase; the companies, the middlemen, and the patent cliff behind the deal wave; the obesity drugs and Lilly's lead; cancer, immunology, and genetic medicine from Casgevy to editing inside the body; vaccines and the US policy upheaval; China's licensing boom and AI's honest scorecard; the FDA's turmoil; and the pricing war, from negotiation to most-favored-nation deals. Worked examples follow the money in a branded drug listed at $1,000 a month and a licensing deal from both sides. Opens with a dated table of the state of the art and a Who's Who.

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